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Full-Text Articles in Molecular Biology
Transcriptional Programming By Thyroid Hormone Receptor Beta Maintains Normal Cell Identity And Suppresses Tumor Growth, Noelle Elizabeth Gillis
Transcriptional Programming By Thyroid Hormone Receptor Beta Maintains Normal Cell Identity And Suppresses Tumor Growth, Noelle Elizabeth Gillis
Graduate College Dissertations and Theses
The overall incidence of thyroid cancer has more than tripled over the past several decades, as has aggressive disease and mortality. The direct relationship between thyroid disease, thyroid hormone levels, and development of thyroid cancer is incomplete. Recent meta-analyses have indicated a higher risk of thyroid cancer for patients with thyroid diseases that reflect an altered thyroid-pituitary signaling axis, which can have profound impacts on the physiology of the thyroid gland. These largely unanswered questions regarding altered thyroid hormone signaling and its consequences for thyroid tumor growth present a significant clinical challenge. This dilemma may come from a lack of …
Characterization Of Epigenetic Plasticity And Chromatin Dynamics In Cancer Cell Models, Diana Lea Gerrard
Characterization Of Epigenetic Plasticity And Chromatin Dynamics In Cancer Cell Models, Diana Lea Gerrard
Graduate College Dissertations and Theses
Cancer progression is driven by cumulative changes that promote and maintain the malignant phenotype. Epigenetic alterations are central to malignant transformation and to the development of therapy resistance. Changes in DNA methylation, histone acetylation and methylation, noncoding RNA expression and higher-order chromatin structures are epigenetic features of cancer, which are independent of changes in the DNA sequence. Despite the knowledge that these epigenetic alterations disrupt essential pathways that protect cells from uncontrolled growth, how these modifications collectively coordinate cancer gene expression programs remains poorly understood. In this dissertation, I utilize molecular and informatic approaches to define and characterize the genome-wide …