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Full-Text Articles in Molecular Biology
Molecular Mechanisms Of Mrna Transport By A Class V Myosin And Cytoplasmic Dynein, Thomas Edward Sladewski
Molecular Mechanisms Of Mrna Transport By A Class V Myosin And Cytoplasmic Dynein, Thomas Edward Sladewski
Graduate College Dissertations and Theses
mRNA localization ensures correct spatial and temporal control of protein synthesis in the cell. Using a single molecule in vitro approach, we provide insight into the mechanisms by which localizing mRNAs are carried by molecular motors on cytoskeletal tracks to their destination.
Budding yeast serves as a model system for studying the mechanisms of mRNA transport because localizing mRNAs are moved on actin tracks in the cell by a single class V myosin motor, Myo4p. Molecular motors that specialize in cargo transport are generally double-headed so that they can "walk" for many microns without dissociating, a feature known as processivity. …