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Full-Text Articles in Molecular Biology
Role Of Endocytic Machinery Regulators In Egfr Traffic And Viral Entry, Insha Mushtaq
Role Of Endocytic Machinery Regulators In Egfr Traffic And Viral Entry, Insha Mushtaq
Theses & Dissertations
STUDY 1: Role of endocytic regulator EHD1 and its binding partner RUSC2 in EGFR traffic
Abstract
Epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase and an oncoprotein in many solid tumors. Cell surface display of EGFR is essential for cellular responses to its ligands. While post activation endocytic trafficking of EGFR has been well elucidated, little is known about mechanisms of basal/pre-activation surface display of EGFR. Here, we identify a novel role of the endocytic regulator EHD1 and a potential EHD1 partner, RUSC2, in cell surface display of EGFR. EHD1 and RUSC2 colocalize with EGFR in vesicular/tubular …