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Full-Text Articles in Molecular Biology
Distinguishing Melanocytic Nevi From Melanoma By Dna Copy Number Changes: Array-Comparative Genomic Hybridization As A Research Tool, Ahmed Ibrahim Mahas
Distinguishing Melanocytic Nevi From Melanoma By Dna Copy Number Changes: Array-Comparative Genomic Hybridization As A Research Tool, Ahmed Ibrahim Mahas
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Skin melanocytes can give rise to different benign and malignant neoplasms. Discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. However, previous studies have shown that in contrast to benign nevi, melanoma demonstrates pervasive chromosomal aberrations. This substantial difference between melanoma and benign nevi formed the idea of exploiting this difference to discriminate between melanoma and benign nevi. Array-comparative genomic hybridization (aCGH) is an approach that can be used on DNA extracted from formalin-fixed paraffin-embedded (FFPE) tissues to assess the entire genome for the presence of changes in DNA copy number. In this study, …
Validation Of A Custom-Made Microarray To Study Human Intestinal Microflora, Harshavardhan Kenche
Validation Of A Custom-Made Microarray To Study Human Intestinal Microflora, Harshavardhan Kenche
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Intestinal microflora refers to all the different species of bacteria that reside in the human gut and is an important organ of the human body because almost all the digestive reactions of the host occur in the intestine. The bacteria of the intestine play a key role in this process by supplementing the intestine with various enzymes and proteins that are required for the digestive process. At the same time, these bacteria were shown to be implicated in a variety of gastrointestinal disorders like Irritable Bowel Syndrome, Inflammatory Bowel Disorder and Gastrointestinal Cancer, but with the current knowledge about the …