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Genome Maintenance Roles Of Polycomb Transcriptional Repressors Bmi1 And Rnf2, Anthony Richard Sanchez Iv
Genome Maintenance Roles Of Polycomb Transcriptional Repressors Bmi1 And Rnf2, Anthony Richard Sanchez Iv
USF Tampa Graduate Theses and Dissertations
The coordination of transcription, replication, and DNA damage response (DDR) is vital for maintaining normal cellular homeostasis. All of these processes take place on the chromatin and thus, the temporal and spatial separation of the factors responsible are necessary for each to be correctly completed. Here we detail several novel processes contributing to this network.
BMI1 is a component of the Polycomb Repressive Complex 1 (PRC1) which plays a key role in maintaining epigenetic silencing programs during development. Recently, BMI1 and other members of PRC1 like RNF2 have been implicated gene silencing during the DDR; however, the mechanism through which …