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The Role Of Brca1 Domains And Motifs In Tumor Suppression, Aneliya Velkova
The Role Of Brca1 Domains And Motifs In Tumor Suppression, Aneliya Velkova
USF Tampa Graduate Theses and Dissertations
Individuals that carry deleterious mutations in the breast and ovarian cancer susceptibility gene 1 (BRCA1) have much more elevated risk to develop breast and/or ovarian cancer than the individuals from the general population. The BRCA1 gene product has been implicated in several aspects of the DNA damage response, but its biochemical function in these processes has remained elusive. In order to probe BRCA1 functions we conducted a yeast two-hybrid screening to identify interacting partners to a conserved motif (Motif 6) in the central region of BRCA1. In this dissertation, we report the identification of the actin-binding protein Filamin A (FLNA) …