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Full-Text Articles in Molecular Biology
Protein-Protein Interactions In Perilpin 5, Erin K. Hughes
Protein-Protein Interactions In Perilpin 5, Erin K. Hughes
Undergraduate Honors Thesis Projects
Many metabolic diseases contribute to a major part of the health crisis in the US. Type II diabetes mellitus and non-alcoholic fatty liver disease are two examples of metabolic diseases that are contributing to the current health crisis. Key to understanding these diseases and their progression is an understanding of neutral lipid metabolism. Perilipins are a class of five conserved proteins that are key regulators of lipid metabolism and are potentially involved in lipid trafficking within cells. The most recently discovered member of the family is perilipin 5, which is expressed most strongly in tissues that are highly oxidative such …
Evidence Of A Perilipin 5 Splice Variant, Brodie Ranzau
Evidence Of A Perilipin 5 Splice Variant, Brodie Ranzau
Undergraduate Honors Thesis Projects
Alternative splicing occurs throughout the human genome, leading to multiple proteins from a single gene. The resulting proteins can be nearly identical or vastly different in how they function. Alternative splicing within the perilipin family has been observed in perilipins 1 and 3, giving rise to proteins with varying functions. In the course of our studies on perilipin 5, an immunoblot signal was observed that corresponded to an approximately 35 kDa protein. Western blot analysis of this protein has revealed its expression in C2C12 cultured myoblasts and in heart and liver mouse tissue. Further analysis of perilipin 5 cDNA through …