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Full-Text Articles in Molecular Biology
Bioinformatics Resources For Microrna Discovery, Alyssa C. Moore, Jonathan S. Winkjer, Tsai-Tien Tseng
Bioinformatics Resources For Microrna Discovery, Alyssa C. Moore, Jonathan S. Winkjer, Tsai-Tien Tseng
Faculty and Research Publications
Biomarker identification is often associated with the diagnosis and evaluation of various diseases. Recently, the role of microRNA (miRNA) has been implicated in the development of diseases, particularly cancer. With the advent of next-generation sequencing, the amount of data on miRNA has increased tremendously in the last decade, requiring new bioinformatics approaches for processing and storing new information. New strategies have been developed in mining these sequencing datasets to allow better understanding toward the actions of miRNAs. As a result, many databases have also been established to disseminate these findings. This review focuses on several curated databases of miRNAs and …
Micrornas Expressed During Viral Infection: Biomarker Potential And Therapeutic Considerations, Jennifer Louten, Michael Beach, Kristina Palermino, Maria Weeks, Gabrielle Holenstein
Micrornas Expressed During Viral Infection: Biomarker Potential And Therapeutic Considerations, Jennifer Louten, Michael Beach, Kristina Palermino, Maria Weeks, Gabrielle Holenstein
Faculty and Research Publications
MicroRNAs (miRNAs) are short sequences of noncoding single-stranded RNAs that exhibit inhibitory effects on complementary target mRNAs. Recently, it has been discovered that certain viruses express their own miRNAs, while other viruses activate the transcription of cellular miRNAs for their own benefit. This review summarizes the viral and/or cellular miRNAs that are transcribed during infection, with a focus on the biomarker and therapeutic potential of miRNAs (or their antagomirs). Several human viruses of clinical importance are discussed, namely, herpesviruses, polyomaviruses, hepatitis B virus, hepatitis C virus, human papillomavirus, and human immunodeficiency virus.