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Dna Interaction And Cytotoxic Activities Of Square Planar Platinum(Ii) Complexes With N, S-Donor Ligands, Mohan N. Patel, Chintan R. Patel, Hardik Joshi, Khyati P. Thakor

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The platinum(II) complexes with N, S-donor ligands have been synthesized and characterized by physicochemical methods viz. elemental, electronic, FT-IR, 1H NMR and LC–MS spectra. The binding mode and potency of the complexes with HS DNA (Herring Sperm) have been examined by absorption titration and viscosity measurement studies. The results revealed that complexes bind to HS DNA via covalent mode with the intrinsic binding constant (Kb) in the range 1.37–7.76 × 105 M−1. Decrease in the relative viscosity of HS DNA also supports the covalent mode of binding. The DNA cleavage activity of synthesized complexes has been carried out …