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Pt-Mal-Lhrh Mediates Breast Cancer Cell Cytotoxicity Through Increased Apoptosis, Kendall E. Collins Nov 2016

Pt-Mal-Lhrh Mediates Breast Cancer Cell Cytotoxicity Through Increased Apoptosis, Kendall E. Collins

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In the United States one in eight women will be afflicted with breast cancer. It is estimated that in 2016 there will be approximately 246,600 new invasive breast cancer cases and 61,000 new non-invasive cases. Triple negative breast cancers account for 15% of all breast cancers and are significantly more aggressive than other subtypes. Treatment options for triple negative breast cancer are limited due to the cancers not expressing the estrogen, progestogen, or herceptin receptors making them unresponsive to hormonal therapy. Our recent work centers around developing a novel chemotherapeutic agent that will direct therapy selectively to triple negative (4T1) …