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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling, Christina Downey
Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling, Christina Downey
Wayne State University Dissertations
ABSTRACT
MOLECULAR MECHANISMS OF PRESSURE-STIMULATED CANCER CELL SIGNALING
by
CHRISTINA DOWNEY
June 2010
Advisor: Dr. Marc Basson, MD, PhD
Major: Cancer Biology
Degree: Doctor of Philosophy
Increased extracellular pressure stimulates cancer cell adhesion by a mechanism that is dependent upon beta-1-integrin activation, an intact cytoskeleton, and FAK and Src activation. By a different mechanism, increased extracellular pressure modulates cancer cell proliferation in a manner that is regulated by protein kinase C, but not Src or an intact cytoskeleton. Previous studies from our laboratory have shown that paxillin is a necessary mediator in the pathway by which pressure stimulates adhesion; however, …