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Spectroscopic Studies Of Cu2+ And Zn2+ Binding To Prodigiosin Analogs, Karen Chichetu, Papireddy Kancharla, Shilah Bonnett, Kevin Reynolds
Spectroscopic Studies Of Cu2+ And Zn2+ Binding To Prodigiosin Analogs, Karen Chichetu, Papireddy Kancharla, Shilah Bonnett, Kevin Reynolds
Student Research Symposium
Prodigiosins are a family of secondary metabolites that were first isolated from the bacterium Serratia marascens. These natural compounds are red pigmented and characterized by a tri-pyrrole skeleton with a C-4 methoxy group. They have been reported to have good biological properties that include anticancer, antimalarial, antimicrobial and immunosuppressive activities. We have synthesized analogs of the natural prodigiosins (prodiginines) to produce a library of biologically active compounds which have improved biological activity and reduced cytotoxicity in human cells. In this work we studied the interaction between prodiginines and Cu2+ and Zn2+ using UV and Mass Spectroscopy techniques. Early results show …