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Publicly Accessible Penn Dissertations

2016

Chimpanzee

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Full-Text Articles in Molecular Biology

Siv Infected Chimpanzees: Consequences Of Long-Term Infection And Potential Intervention Strategies, Hannah J. Barbian Jan 2016

Siv Infected Chimpanzees: Consequences Of Long-Term Infection And Potential Intervention Strategies, Hannah J. Barbian

Publicly Accessible Penn Dissertations

Simian immunodeficiency virus of chimpanzees (SIVcpz) is widespread in wild-living chimpanzees and can cause mortality and AIDS-like immunopathology. However, due to limited access to naturally infected chimpanzees, little is known about SIVcpz pathogenesis and potential intervention strategies that might be effective in captivity or in the wild. Given the central role of the intestinal microbiome in mammalian health, I asked whether gut microbial constituents could reveal any insights into SIVcpz-associated pathogenicity. I characterized the gut microbiome and virome of SIVcpz infected and uninfected chimpanzees in Gombe National Park, Tanzania. I found that SIVcpz infected chimpanzees retain a stable gut microbiome ...