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Full-Text Articles in Molecular Biology

Haloferax Volcanii Strategies To Regulate Type Iv Pilus Dependent Adhesion And Microcolony Formation, Rianne Nicole Esquivel Jan 2016

Haloferax Volcanii Strategies To Regulate Type Iv Pilus Dependent Adhesion And Microcolony Formation, Rianne Nicole Esquivel

Publicly Accessible Penn Dissertations

Microorganisms can utilize type IV pili to initiate and maintain biofilms - microbial communities that provide protection against stressful conditions. Because environmental conditions change suddenly, microorganisms have evolved multiple mechanisms to rapidly transition from a planktonic to sessile cell state. Despite the presence of archaea alongside bacteria throughout the environment, including the human microbiome, little is known about how these organisms form and maintain biofilms. Here we use genetic, microscopic and biochemical techniques to investigate multiple strategies the model archaeon Haloferax volcanii employs to permit effective adhesion and microcolony formation, early steps in biofilm formation and maturation, as well as eventual ...


Siv Infected Chimpanzees: Consequences Of Long-Term Infection And Potential Intervention Strategies, Hannah J. Barbian Jan 2016

Siv Infected Chimpanzees: Consequences Of Long-Term Infection And Potential Intervention Strategies, Hannah J. Barbian

Publicly Accessible Penn Dissertations

Simian immunodeficiency virus of chimpanzees (SIVcpz) is widespread in wild-living chimpanzees and can cause mortality and AIDS-like immunopathology. However, due to limited access to naturally infected chimpanzees, little is known about SIVcpz pathogenesis and potential intervention strategies that might be effective in captivity or in the wild. Given the central role of the intestinal microbiome in mammalian health, I asked whether gut microbial constituents could reveal any insights into SIVcpz-associated pathogenicity. I characterized the gut microbiome and virome of SIVcpz infected and uninfected chimpanzees in Gombe National Park, Tanzania. I found that SIVcpz infected chimpanzees retain a stable gut microbiome ...