Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Genetics and Genomics (2)
- Analytical Chemistry (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Applied Statistics (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
-
- Biochemistry (1)
- Bioinformatics (1)
- Biology (1)
- Biostatistics (1)
- Cardiology (1)
- Cardiovascular Diseases (1)
- Cellular and Molecular Physiology (1)
- Chemistry (1)
- Computational Biology (1)
- Computer Sciences (1)
- Diagnosis (1)
- Diseases (1)
- Integrative Biology (1)
- Marine Biology (1)
- Medical Biomathematics and Biometrics (1)
- Medical Molecular Biology (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Medicine and Health Sciences (1)
- Other Genetics and Genomics (1)
- Physical Sciences and Mathematics (1)
- Physiology (1)
Articles 1 - 3 of 3
Full-Text Articles in Molecular Biology
Bayesian Analytical Approaches For Metabolomics : A Novel Method For Molecular Structure-Informed Metabolite Interaction Modeling, A Novel Diagnostic Model For Differentiating Myocardial Infarction Type, And Approaches For Compound Identification Given Mass Spectrometry Data., Patrick J. Trainor
Electronic Theses and Dissertations
Metabolomics, the study of small molecules in biological systems, has enjoyed great success in enabling researchers to examine disease-associated metabolic dysregulation and has been utilized for the discovery biomarkers of disease and phenotypic states. In spite of recent technological advances in the analytical platforms utilized in metabolomics and the proliferation of tools for the analysis of metabolomics data, significant challenges in metabolomics data analyses remain. In this dissertation, we present three of these challenges and Bayesian methodological solutions for each. In the first part we develop a new methodology to serve a basis for making higher order inferences in metabolomics, …
Divergent Responses Of Larval And Juvenile Blue Mussels To Low Salinity Exposure, Melissa A. May
Divergent Responses Of Larval And Juvenile Blue Mussels To Low Salinity Exposure, Melissa A. May
Electronic Theses and Dissertations
In this study, we compared the osmotic stress response of larval and juvenile blue mussels (Mytilus edulis) at the transcriptomic, metabolomic, and whole organism levels. Blue mussels inhabit coastal areas, where they face climate-induced reductions in nearshore salinity. Despite their ecological and economic importance, scientists do not fully understand the underlying transcriptomic and cellular mechanisms of the osmotic stress response in blue mussels or how the ability to respond to stress changes throughout development. Blue mussels spend the first weeks of life developing through several larval stages in the plankton. These early life history stages are more vulnerable …
Biochemical And Molecular Assessment Of Toxicity Of Primaquine Metabolites On Erythrocytes, Jagrati Jain
Biochemical And Molecular Assessment Of Toxicity Of Primaquine Metabolites On Erythrocytes, Jagrati Jain
Electronic Theses and Dissertations
The 8-aminoquinoline (8AQ) antimalarial drug primaquine (PQ) is the only drug for prevention of malaria relapse. Moreover, PQ also has gametocytocidal activity against Plasmodium falciparum. However, clinical use of PQ has been limited due to its hemolytic toxicity, especially in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals. Phenolic and quinone metabolites generated via cytochrome P450-dependent pathways appear to be responsible for hemolytic effects of PQ. However, the mechanism for the hemolytic toxicity of PQ is still poorly understood. To explore the mechanism, targets, and pathways for toxicity of PQ, normal and G6PDd human erythrocytes were treated with the potential hemotoxic metabolites of …