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Full-Text Articles in Molecular Biology
Prevention Of Chronic Inflammation By Targeting Macrophage Integrin Adb2, Cady Forgey
Prevention Of Chronic Inflammation By Targeting Macrophage Integrin Adb2, Cady Forgey
Electronic Theses and Dissertations
Macrophage integrin aDb2 promotes macrophage retention and accumulation within inflamed tissue, a key event in development of chronic inflammation. Recently, the P5 peptide was identified as a specific inhibitor for integrin aDb2 interaction with 2-(ω-carboxyethyl) pyrole (CEP), a ligand at inflammatory sites. This thesis aims to identify integrin aD I-domain amino acids involved in binding P5 peptide and likewise to CEP. We propose that non-conserved, basic amino acids of the integrin aDb2 I-domain are responsible for binding to P5 peptide and likewise to CEP. Eight amino acids were analyzed by …