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Full-Text Articles in Molecular Biology
Cancer And Quiescence: Investigating How The Dream Complex And Retinoblastoma Regulate The Cell Cycle, Lydia Rotman
Cancer And Quiescence: Investigating How The Dream Complex And Retinoblastoma Regulate The Cell Cycle, Lydia Rotman
Dissertations, Master's Theses and Master's Reports
An estimated 1.9 million people in the United States will be diagnosed with cancer in 2022. Cancer is characterized by uncontrolled cell growth, resulting from loss-of-function of key cell cycle regulatory proteins. The retinoblastoma protein (pRb) and p130, are two proteins that regulate cellular entry into the cell cycle. Both pRb and p130 repress expression of cell cycle genes, with pRb interacting with and suppressing E2F-DP transcriptional activators and p130 assembling in the DREAM transcriptional repressor complex. When normal cells receive signals to enter the cell cycle, cyclin and cyclin-dependent kinase (CDK) complexes phosphorylate pRb and p130, causing both to …