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Characterization Of The Role Of Acetylated Ape1 In Dna Damage Repair And Transcriptional Regulation, Shrabasti Roychoudhury
Characterization Of The Role Of Acetylated Ape1 In Dna Damage Repair And Transcriptional Regulation, Shrabasti Roychoudhury
Theses & Dissertations
Apurinic/apyrimidinic (AP) sites are the most frequently formed DNA lesions in the genome. The primary enzyme to repair AP sites in mammalian cells is the AP endonuclease (APE1), which functions through the base excision repair (BER) pathway. Mammalian APE1 has a unique N-terminal unstructured tail and has both DNA repair and transcriptional regulatory activities. Our lab discovered that APE1 can be regulated via post-translational acetylation of lysine residues 6, 7, 27, 31, and 32. The role of mammalian APE1 in repair has been extensively studied and well characterized. However, the regulatory role of APE1 acetylation (AcAPE1) in the context of …