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The Role Of The Intermembrane Domain Of Mulan In Mitophagy And Cell Death, Jared M. Herbert
The Role Of The Intermembrane Domain Of Mulan In Mitophagy And Cell Death, Jared M. Herbert
Honors Undergraduate Theses
Mulan is an E3 ubiquitin ligase and an E3 SUMO ligase embedded in the outer mitochondrial membrane. Mulan plays a major role in various cell processes including cell growth, mitophagy, apoptosis, and mitochondrial dynamics. In addition, its deregulation is involved in the development and progression of several human disorders such as neurodegeneration and heart disease. There are two main discernible domains in Mulan: a large cytoplasmic domain that encodes the RING-finger motif and carries out the catalytic activity of the protein; the second domain of Mulan is exposed to the intermembrane space of mitochondria, and its function remains unknown. This …