Molecular Biology Commons^™

Stealth Carbon Nanotubes: Strategies To Coat Carbon Nanotubes To Prevent Opsonization And Improve Biodistribution, Nalinikanth Kotagiri

Graduate Theses and Dissertations

Carbon nanotubes (CNT) have recently been in the limelight for its potential role in disease diagnostics and therapeutics. Even before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages and sequestration to liver and spleen for eventual elimination from the body. We believe coating CNT with biocompatible and opsonin resistant moieties will not only help CNT in traversing the blood stream to reach the target organ, but also improve biodistribution tremendously. We set out to achieve this by firstly identifying a new compound, mAmp, which is a fluorescent derivative of the …