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Mutations In Caveolin Binding Motif Alter Human Follicle Stimulating Hormone Receptor Signaling, Katarina Zahedi
Mutations In Caveolin Binding Motif Alter Human Follicle Stimulating Hormone Receptor Signaling, Katarina Zahedi
Honors Theses
Globally, there are about 48 million couples and 186 million individuals of reproductive age that are affected by infertility. Some cases of infertility in both men and women have been attributed to impaired follicle stimulating hormone (FSH) signaling. The lack of proper function of the cognate receptor for FSH (FSHR) could contribute to infertility since the biochemical signal generated by FSH binding to FSHR stimulates the production of a sperm-stabilizing protein in males and follicle maturation in females. It has been demonstrated that human FSHR (hFSHR) localizes to lipid rafts, which are rigid and detergent-resistant microdomains in the cell membrane. …