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Mechanisms Of Regulation Of Tau Ires Mediated Translation, Niza Nemkul
Mechanisms Of Regulation Of Tau Ires Mediated Translation, Niza Nemkul
Dissertations & Theses (Open Access)
The translation of most eukaryotic mRNAs occurs in a cap-dependent manner. However, a subset of mRNAs are capable of initiating translation in a cap-independent manner by utilizing sequences in their 5’ UTR called IRES. It was previously shown that the 5’ UTR of the tau mRNA contains an IRES. In this study I show that IRES dependent translation of tau IRES is regulated at multiple levels in order to regulate the expression of the tau protein.
Tau protein is ubiquitously expressed but is concentrated in the brain. In this study, I utilized neural and non-neural cell lines to show that …