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Ligand-independent Activity; Microarray Screen; Heregulin; Anti-adhesion; Heterodimer; Phosphorylation; ErbB2 Signaling; Receptor Tyrosine Kinase; Membrane Mucin; Muc4; Epidermal Growth Factor Receptor
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Muc4 Modulation Of Ligand-Independent Erbb2 Signaling, Goldi Attias Kozloski
Muc4 Modulation Of Ligand-Independent Erbb2 Signaling, Goldi Attias Kozloski
Goldi A Kozloski
The membrane mucin Muc4 is a heterodimer, bi-functional glycoprotein complex that is normally expressed in epithelial tissue. Functional studies on the extracellular mucin subunit of Muc4 have shown that it acts to promote anti-adhesion properties by sterically interfering with cell-cell and cell-matrix interactions and that the extent of this effect is directly associated with the number of tandem repeats on this subunit. Functional studies on the transmembrane subunit of Muc4 have shown that this subunit participates in intracellular signaling through interaction with the receptor tyrosine kinase ErbB2. This role of Muc4 was shown to be mediated by stabilizing the heregulin …