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The Endosomal Sorting Complex Required For Transport Pathway Mediates Chemokine Receptor Cxcr4 Akt Signaling By Promoting Lysosomal Degradation Of Mtor Antagonist Deptor, Rita Ramkaran Verma
The Endosomal Sorting Complex Required For Transport Pathway Mediates Chemokine Receptor Cxcr4 Akt Signaling By Promoting Lysosomal Degradation Of Mtor Antagonist Deptor, Rita Ramkaran Verma
Dissertations
The chemokine receptor CXCR4 is a member of the G protein-coupled receptor (GPCR) family. The cognate ligand for CXCR4 is the C-X-C chemokine known as CXCL12. The CXCL12/CXCR4 signaling axis is essential for a number of developmental processes including organogenesis, vascularization of the GI tract and hematopoiesis. Dysregulated CXCR4 signaling is also implicated in a variety of pathological conditions such as WHIM (Warts, Hypogammaglobunemia, Infections and myelokathexis) syndrome, cardiovascular disease and cancer. Despite its role in several pathologies, the molecular mechanisms mediating CXCR4 signaling are not completely understood. Upon CXCL12 binding to CXCR4, several signaling pathways are activated including the …