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Full-Text Articles in Molecular Biology
The Role Of Cyp33 In Mll Mediated Gene Repression, Steven D. Poppen
The Role Of Cyp33 In Mll Mediated Gene Repression, Steven D. Poppen
Dissertations
Mixed Lineage Leukemia (MLL) is a multidomain protein whose gene is translocated in a subset of AML leukemias. Translocation of the MLL gene is present in approximately five percent of adult acute leukemias and ten percent of pediatric leukemias (Daser, A 2004, Look, A 1997, Huret, J 2001) Patients presenting in the clinic at the time of diagnosis with an MLL fusion have been shown to respond poorly to treatment and have a worse prognosis than matched wild type MLL patients (Rubnitz, J 1994, Rubnitz, J 1999). Novel therapies therefore are needed in order to more effectively treat patients with …
Determination Of An Interaction Between Nipped B-Like Protein And Mll, Adam Robert Marek
Determination Of An Interaction Between Nipped B-Like Protein And Mll, Adam Robert Marek
Master's Theses
The Mixed Lineage Leukemia (MLL) protein serves as a positive transcriptional regulator during hematopoietic and embryonic development. The MLL gene can undergo chromosomal translocations producing leukemia-causing fusions that retain the MLL amino-terminus, including the repression domain. A recent yeast two-hybrid screening used the MLL repression domain as bait and yielded nine positive clones of Nipped B-like (NIPBL).
NIPBL is a crucial member of the cohesin complex, which functions in the segregation of sister chromatids during cell division. However, recent evidence suggests the cohesin complex can also function as a transcriptional regulator.
In this study, we wanted to confirm this interaction …