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Full-Text Articles in Molecular Biology
Deregulation Of Polycomb Repressive Complex-2 In Mantle Cell Lymphoma Confers Growth Advantage By Epigenetic Suppression Of, Christos Demosthenous, Shiv K Gupta, Jing Sun, Yongsen Wang, Tammy P Troska, Mamta Gupta
Deregulation Of Polycomb Repressive Complex-2 In Mantle Cell Lymphoma Confers Growth Advantage By Epigenetic Suppression Of, Christos Demosthenous, Shiv K Gupta, Jing Sun, Yongsen Wang, Tammy P Troska, Mamta Gupta
Biochemistry and Molecular Medicine Faculty Publications
The polycomb repressive complex 2 (PRC2) maintains the transcriptional repression of target genes through its catalytic component enhancer of zeste homolog 2 (EZH2). Through modulating critical gene expression, EZH2 also plays a role in cancer development and progression by promoting cancer cell survival and invasion. Mutations in EZH2 are prevalent in certain B-cell lymphoma subtypes such as diffuse large cell lymphoma and follicular lymphoma; while no EZH2 mutation has been reported in the mantle cell lymphoma (MCL). Here we demonstrate that the PRC2 components EZH2, EED and SUZ12 are upregulated in the MCL cells as compared to normal B-cells. Moreover, …