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Full-Text Articles in Molecular Biology
A Test Of The Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action In Human Placenta, Katherine Geromini
A Test Of The Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action In Human Placenta, Katherine Geromini
Masters Theses 1911 - February 2014
Thyroid hormone is essential for normal brain development and recognition of this has led to universal screening of newborns for thyroid function to ensure that circulating levels of thyroid hormone are within a range known to be supportive of normal growth and mental development. Environmental chemicals that interfere with thyroid function are known to inhibit normal growth and mental development. Work from our lab and from labs internationally demonstrates in animal systems that some industrial chemicals such as PCBs, PBDEs, and others may interact with the thyroid hormone receptor(s) in ways that are not predicted by changes in serum thyroid …
Proteolytic Regulation Of Ctra, The Master Regulator Of Cell Cycle In Caulobacter Crescentus, Amber M. Cantin
Proteolytic Regulation Of Ctra, The Master Regulator Of Cell Cycle In Caulobacter Crescentus, Amber M. Cantin
Masters Theses 1911 - February 2014
Cell cycle progression in Caulobacter crescentus depends on the master regulator, CtrA. During the transition from swarmer to stalk cell (G1 to S phase), CtrA is degraded by the AAA+ protease ClpXP and levels rise again in the predivisional stage. The focus of this work is to explore how cyclic, regulated degradation is controlled. CtrA is known to bind to the origin of replication, thereby suppressing replication, so we first asked if DNA binding had an effect on CtrA stability. CtrA is readily degraded by ClpXP on its own, but when bound to DNA containing the proper binding sites, degradation …
Investigation Of Differential Vector Competence Of Bartonella Quintana In Human Head And Body Lice, Domenic J. Previte
Investigation Of Differential Vector Competence Of Bartonella Quintana In Human Head And Body Lice, Domenic J. Previte
Masters Theses 1911 - February 2014
Human head and body lice are obligatory hematophagous ectoparasites that belong to a single species Pediculus humanus. Only body lice, however, are vectors of the infections gram-negative bacteria Bartonella quintana. Due to their near identical genomes, yet differential vector competency, head and body lice provide an ideal model system to study an insects ability to gain or lose vector competency. Using our in vitro louse rearing system, we have infected both head and body lice with a blood containing B. quintana in order to detect differences in B. quintana proliferation between head and body lice as well as …