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- Keyword
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- Bifc; Fluorescent tools; Large stokes shift; M pfc; Mcherry; Mycobacterium tuberculosis; Tb (1)
- Binary; Deoxyribozyme; Detection; Dnazyme; Drug; Drugr; Mtb; Mycobacterium; Nucleotide; Polymorphism; Resistance; Single; Snp; Tb; Tuberculosis (1)
- Falciparum; Pfmrk; Pfpk5; Pfpk6; Plasmodium (1)
- Orp 10 (1)
- Very low density lipoprotein (1)
Articles 1 - 4 of 4
Full-Text Articles in Molecular Biology
Regulation Of Vldl Trafficking By Orp 10, Philip A. Wessels
Regulation Of Vldl Trafficking By Orp 10, Philip A. Wessels
HIM 1990-2015
Of the challenges facing the improvement of human health, none has taken the forefront quite like the endeavor to discover novel treatments for heart disease. As heart disease has now become the leading cause of death throughout the world [1], the medical community has made incredible strides in the mission to treat atherosclerosis which is the major contributor to heart disease. Very Low Density Lipoproteins (VLDL) are secreted by the liver and subsequently converted to Low Density Lipoproteins (LDL). Many factors contribute to the narrowing of the arterial walls, however oxidized LDL is the main factor that leads to the …
Detection Of Drug-Resistance Conferring Snps In Mycobacterium Tuberculosis Using Binary Dnazymes, Marina Addario
Detection Of Drug-Resistance Conferring Snps In Mycobacterium Tuberculosis Using Binary Dnazymes, Marina Addario
HIM 1990-2015
Mycobacterium tuberculosis (Mtb) is the pathogen that causes Tuberculosis (TB) and is responsible for an average of 1.5 million deaths annually. Although a treatment regimen does exist, Multi-Drug Resistant (MDR-TB) and eXtremely Drug Resistant (XDR-TB) TB strains are becoming a more prevalent concern partly due to failure of patient compliance with the current six to nine month drug treatment regimen. The current diagnostic methods are not able to identify these MDR and XDR-TB strains efficiently therefore more effective point-of-care (POC) diagnostics and drug susceptibility testing (DST) are urgently needed to detect drug resistance and facilitate prompt, appropriate treatment plans. In …
Development Of Novel Fluorescent Tools For Investigating Virulence Factors And Drug Susceptibility In Mycobacterium Tuberculosis, Kaley Wilburn
Development Of Novel Fluorescent Tools For Investigating Virulence Factors And Drug Susceptibility In Mycobacterium Tuberculosis, Kaley Wilburn
HIM 1990-2015
Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), a life-threatening disease primarily affecting the lungs that infects about one third of the world's population and causes 1.3 million deaths annually. It is estimated that TB has been infecting humans for around 70,000 years and has killed more people than any other infectious disease. The highly effective, persistent, and multifaceted virulence strategies that have allowed Mtb to continue to spread and thrive for so long are still poorly understood at the molecular level. This lack of knowledge contributes to ongoing challenges to curing TB. Although drugs capable of killing …
Elucidating The Molecular Pathway Of Atypical Plasmodium Falciparum Kinases Through Substrate Characterization, Daniel Segarra
Elucidating The Molecular Pathway Of Atypical Plasmodium Falciparum Kinases Through Substrate Characterization, Daniel Segarra
HIM 1990-2015
Plasmodium falciparum, the organism responsible for the most prevalent and most virulent cases of malaria in humans, poses a major burden to the developing world. The parasite is increasingly developing resistance to traditional therapies, such as chloroquine, so the need to determine novel drug targets is more prevalent than ever. One such method involves targeting proteins unique to the malarial proteome that do not have homologues in humans. An especially promising group of targets are protein kinases, which are involved in many different biochemical pathways within the cell. Eukaryotic cell cycle progression is moderated by a family of protein kinases …