Molecular Biology Commons^™

Protein-Ligand Interactions And Allosteric Regulation Of Activity In Dream Protein, Walter G. Gonzalez

FIU Electronic Theses and Dissertations

Downstream regulatory antagonist modulator (DREAM) is a calcium sensing protein that co-assembles with K_V4 potassium channels to regulate ion currents as well as with DNA in the nucleus, where it regulates gene expression. The interaction of DREAM with A-type K_V4 channels and DNA has been shown to regulate neuronal signaling, pain sensing, and memory retention. The role of DREAM in modulation of pain, onset of Alzheimer’s disease, and cardiac pacemaking has set this protein as a novel therapeutic target. Moreover, previous results have shown a Ca²⁺ dependent interaction between DREAM and K_V4/DNA involving …