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Characterization Of Two Novel Gene Regulatory Systems In The Zoonotic Bacterium Bartonella Henselae, Nhan Tu
Characterization Of Two Novel Gene Regulatory Systems In The Zoonotic Bacterium Bartonella Henselae, Nhan Tu
USF Tampa Graduate Theses and Dissertations
The genus Bartonella contains Gram-negative arthropod-borne bacteria that are found in many small animal reservoirs and are capable of causing human disease. Bacteria utilize a general stress response system to combat stresses from their surrounding environments. In α-proteobacteria, the general stress response system uses an alternate σ factor as the main regulator and incorporates it with a two-component system into a unique system. Our study identifies the general stress response system in the α-proteobacterium, Bartonella henselae, where the gene synteny is conserved and both the PhyR and alternate σ factor have similar sequence and domain structures with other α-proteobacteria. …