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Full-Text Articles in Molecular Biology
Structure And Evolution Of Lizard Immunity Genes, Trent Santonastaso
Structure And Evolution Of Lizard Immunity Genes, Trent Santonastaso
University of New Orleans Theses and Dissertations
One of the most important gene families to play a role in adaptive immunity is the major histocompatibility complex (MHC). MHC class II loci are considered to be the most variable loci in the vertebrate genome, and studies have shown that this variability can be maintained through complex co-evolutionary dynamics between host and parasite. Despite the rich body of research into the MHC, there is comparatively little understanding of its genomic architecture in reptiles. Similarly, loci associated with innate immunity have received little attention in reptiles compared to other vertebrates. In the first chapter, we investigated the structure and organization …
Role Of Ime4 Protein In Pho Regulon Of S.Cerevisiae., Jenisha Ghimire
Role Of Ime4 Protein In Pho Regulon Of S.Cerevisiae., Jenisha Ghimire
University of New Orleans Theses and Dissertations
In the yeast Saccharomyces cerevisiae, the IME4 methyltransferase, interacts genetically with methyl binding protein, Pho92, to affect the expression of PHO regulon target genes. Cells mutant in IME4 or PHO92 show increases in the RNA abundance of PHO regulon target genes. The increase in the RNA abundance of the PHO regulon target genes is not additive in the cells double mutant in IME4 and PHO92. Hence, Ime4 and Pho92 interact in a single pathway in PHO regulon. Surprisingly, cells overexpressing IME4 and MUM2 shows increase in some PHO regulon target genes, indicating that IME4 affects the PHO regulon target …