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The Role Of Rmta In The Opportunistic Pathaogen Aspergillus Fumigatus, Roshan Dahal
The Role Of Rmta In The Opportunistic Pathaogen Aspergillus Fumigatus, Roshan Dahal
Graduate Research Theses & Dissertations
The fungus Aspergillus fumigatus is an opportunistic human pathogen capable of causing
a life-threatening systemic lung infection known as invasive aspergillosis among immune compromised
patients. This group includes individuals infected with HIV, people with hematological
malignancies, solid organ transplant patients, persons with genetic immunodeficiency and cancer
patient undergoing chemotherapy. Due to the medical relevance of this organism, it is imperative
to discover novel genetic elements to design antifungal drugs against A. fumigatus dissemination,
virulence and survival during human infection. Previously, the putative arginine methyltransferase
gene rmtA was characterized in the model organism Aspergillus nidulans and the opportunistic
plant pathogen Aspergillus …