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Full-Text Articles in Molecular Biology
Exploring The Interactions Between Sars-Cov-2 And Host Proteins., Sojan Shrestha
Exploring The Interactions Between Sars-Cov-2 And Host Proteins., Sojan Shrestha
School of Biological Sciences: Dissertations, Theses, and Student Research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current pandemic, Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 is considered to be of zoonotic origin; it originated in non-human animals and was transmitted to humans. Since the early stage of the pandemic, however, the evidence of transmissions from humans to animals (reverse zoonoses) has been found in multiple animal species including mink, white-tailed deer, and pet and zoo animals. Furthermore, secondary zoonotic events of SARS-CoV-2, transmissions from animals to humans, have been also reported. It is suggested that non-human hosts can act as SARS-CoV-2 reservoirs where accumulated …
The Mechanism Of Small Rna Biogenesis, Degradation, And Function In Arabidopsis, Meng Xie
The Mechanism Of Small Rna Biogenesis, Degradation, And Function In Arabidopsis, Meng Xie
School of Biological Sciences: Dissertations, Theses, and Student Research
Eukaryotic small RNAs play important roles in many biological processes through sequence-specific RNA silencing. In plants, there are mainly two small RNAs triggering gene silencing: microRNAs (miRNAs) and small interfering RNAs (siRNAs). The biogenesis and precise regulation of small RNA abundance are crucial for plant growth, development, genomic stability, and the resistance to both abiotic and biotic stresses. In this study, we used Arabidopsis thaliana, the model plant, to study the mechanism of RNA-directed DNA methylation (RdDM), in which siRNAs can trigger DNA methylation and gene silencing. In addition, we investigated the mechanism of miRNA biogenesis and degradation. For …