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Full-Text Articles in Molecular Biology
Dissecting Interactions Across Gene Regulatory Layers In C. Elegans, Morgan Taylor
Dissecting Interactions Across Gene Regulatory Layers In C. Elegans, Morgan Taylor
Biological Sciences Theses and Dissertations
The nematode Caenorhabditis elegans is a powerful tool for studying nervous system genetics. Though relatively simple compared to mammals, C. elegans boasts a remarkably well-conserved neuronal genome and proteome, and its utility in the characterization of neuronal genes has been well-established. However, gene expression is often controlled by complex interactions between multiple genes, and teasing apart the functions of individual genes within such networks remains a challenge. Dissecting these interaction networks is crucial in determining the multifaceted functions of important, conserved regulatory genes. Here we explore interactions between gene regulatory layers in the C. elegans nervous system, employing a synthetic …
Peroxiredoxin 6 And Inflammation In Alzheimer's Disease, Jared Ferrell-Penniman
Peroxiredoxin 6 And Inflammation In Alzheimer's Disease, Jared Ferrell-Penniman
Biological Sciences Theses and Dissertations
Alzheimer’s disease (AD) is known for its debilitating symptoms and poor prognosis. However, despite intense research into neurodegenerative diseases, there are few therapies targeted at the underlying mechanisms of the disease. Oxidative stress (OS) and inflammation are cellular phenomena thought to be key to the progression of the disease. Critically, peroxiredoxin 6 (Prx6), an antioxidant protein with multiple functions, has been identified from mammalian studies as a potential regulator of both OS and inflammation that may have a specific effect on AD. This project seeks to elucidate the role of Prx6 in AD as well as the underlying mechanisms. Drosophila …