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Insight Into Translational Activation In Yeast Mitochondria, Julia Lynn Jones
Insight Into Translational Activation In Yeast Mitochondria, Julia Lynn Jones
Graduate School of Biomedical Sciences Theses and Dissertations
Mitochondrial function depends on over a thousand proteins, of which the majority are nuclear DNA-encoded and approximately one percent are mitochondrial DNA-encoded. The mitochondrial DNA of Saccharomyces cerevisiae contains eight protein-encoding genes, seven of which are required for proper function of the respiratory complexes and one encodes a ribosomal protein. The bigenomic nature of the oxidative phosphorylation complexes requires coordinated expression and regulation from both the nuclear and the mitochondrial genomes. It is currently unclear how this regulatory network operates. However, it is thought that nuclear genome-encoded messengers localized to the mitochondria aid in this coordination.
A family of proteins …