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Articles 1 - 4 of 4
Full-Text Articles in Molecular Biology
The Utilization Of Host-Derived Compounds By Gram-Negative Bacteria, Lauren Alexandra Hinkel
The Utilization Of Host-Derived Compounds By Gram-Negative Bacteria, Lauren Alexandra Hinkel
Graduate College Dissertations and Theses
The increase in multidrug resistance (MDR) among bacterial pathogens is an ongoing threat to public health, with the CDC estimating more than 2.8 million MDR infections in the United States each year, and greater than 35,000 deaths annually. Gram-negative bacteria possess intrinsic mechanisms to resist available therapeutics and are frequently responsible for difficult-to-treat nosocomial, blood stream, and soft tissue infections. In addition to biophysical and genetic MDR mechanisms, Gram negatives are metabolically versatile, enabling them to utilize host-derived nutrients to promote proliferation and colonization within the host. The metabolic versatility of Gram-negative bacteria is due, in part, to the transcription …
Evidence For The Involvement Of Runx1 And Runx2 In Maintenance Of The Breast Cancer Stem Cell Phenotype, Mark Fitzgerald
Evidence For The Involvement Of Runx1 And Runx2 In Maintenance Of The Breast Cancer Stem Cell Phenotype, Mark Fitzgerald
Graduate College Dissertations and Theses
In the United States, metastatic breast cancer kills approximately 40,000 women and 400 men annually, and approximately 200,000 new cases of breast cancer are diagnosed each year. Worldwide, breast cancer is the leading cause of cancer deaths among women. Despite advances in the detection and treatment of metastatic breast cancer, mortality rates from this disease remain high because the fact is that once metastatic, it is virtually incurable. It is widely accepted that a major reason breast cancer continues to exhibit recurrence after remission is that current therapies are insufficient for targeting and eliminating therapy-resistant cancer cells. Emerging research has …
Target Identification Strategies For Mmv Malaria Box Inhibitors Of Toxoplasma Gondii Growth, Jenna Elizabeth Foderaro
Target Identification Strategies For Mmv Malaria Box Inhibitors Of Toxoplasma Gondii Growth, Jenna Elizabeth Foderaro
Graduate College Dissertations and Theses
Small molecule screening is commonly used to discover lead compounds for drug development, but it can also be a powerful way to identify chemical probes for studying biological mechanisms. Our lab uses small molecules to study the mechanisms by which the protozoan parasite Toxoplasma gondii infects and replicates within its hosts. In this work, we employed a fluorescence-based assay to screen the Medicines for Malaria Venture (MMV) Open Access Malaria box for compounds that affect T. gondii growth. The box contains 400 previously identified small-molecule inhibitors of the related parasite, Plasmodium falciparum. We identified 79 hits, including a 2,4-diaminoquinazoline (MMV006169; …
Mechanisms And Dynamics Of Oxidative Dna Damage Repair In Nucleosomes, Wendy J. Cannan
Mechanisms And Dynamics Of Oxidative Dna Damage Repair In Nucleosomes, Wendy J. Cannan
Graduate College Dissertations and Theses
DNA provides the blueprint for cell function and growth, as well as ensuring continuity from one cell generation to the next. In order to compact, protect, and regulate this vital information, DNA is packaged by histone proteins into nucleosomes, which are the fundamental subunits of chromatin. Reactive oxygen species, generated by both endogenous and exogenous agents, can react with DNA, altering base chemistry and generating DNA strand breaks. Left unrepaired, these oxidation products can result in mutations and/or cell death. The Base Excision Repair (BER) pathway exists to deal with damaged bases and single-stranded DNA breaks. However, the packaging of …