Molecular Biology Commons^™

Transcriptional Cross Talk Within The Mar-Sox-Rob Regulon In Escherichia Coli Is Limited To The Rob And Marrab Operons, Lon Chubiz, George Glekas, Christopher Rao

Biology Department Faculty Works

Bacteria possess multiple mechanisms to survive exposure to various chemical stresses and antimicrobial compounds. In the enteric bacterium Escherichia coli, three homologous transcription factors—MarA, SoxS, and Rob—play a central role in coordinating this response. Three separate systems are known to regulate the expression and activities of MarA, SoxS, and Rob. However, a number of studies have shown that the three do not function in isolation but rather are coregulated through transcriptional cross talk. In this work, we systematically investigated the extent of transcriptional cross talk in the mar-sox-rob regulon. While the three transcription factors were found to have the potential …