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Molecular Biology Commons

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Genetics

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2012

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Full-Text Articles in Molecular Biology

Higher-Order Chromatin Organization In Hematopoietic Transcription, Wulan Deng Jan 2012

Higher-Order Chromatin Organization In Hematopoietic Transcription, Wulan Deng

Publicly Accessible Penn Dissertations

Coordinated transcriptional networks underlie complex developmental processes. Transcription factors play central roles in such networks by binding to core promoters and regulatory elements and thereby controlling transcription activities and chromatin states in the genome. GATA1 is a hematopoietic transcription factor that controls multiple hematopoietic lineages by activating and repressing gene expression, yet the in vivo mechanisms that specify these opposing activities are unknown. By examining the composition of GATA1 associated protein complexes in a genetic complementary erythroid cell system as well as through the use of tiling arrays, we found that a multi-protein complex containing SCL/TAL1, LMO2, Ldb1, and ...