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Full-Text Articles in Molecular Biology
Exendin‐4 Enhances Osteogenic Differentiation Of Adipose Tissue Mesenchymal Stem Cells Through The Receptor Activator Of Nuclear Factor‐Kappa B And Osteoprotegerin Signaling Pathway, Sarah A. Habib, Mohamed M. Kamal, Shohda A. El-Maraghy, Mahmoud A. Senousy
Exendin‐4 Enhances Osteogenic Differentiation Of Adipose Tissue Mesenchymal Stem Cells Through The Receptor Activator Of Nuclear Factor‐Kappa B And Osteoprotegerin Signaling Pathway, Sarah A. Habib, Mohamed M. Kamal, Shohda A. El-Maraghy, Mahmoud A. Senousy
Pharmacy
The capability of mesenchymal stem cells (MSCs) to repair bone damage and defects has long been investigated. The receptor activator of nuclear factorkappa B (RANK), its ligand (RANKL) and the decoy receptor osteoprotegerin (OPG) axis is crucial to keep the equilibrium between osteoblastic and osteoclastic activity. Exendin‐4 utilization increased bone formation and enhanced bone integrity. This study aimed to investigate the mentioned axis and determine the effect of exendin‐4 upon adipose mesenchymal stem cells (Ad‐MSCs) osteogenic differentiation. Ad‐MSCs were isolated from rat epididymal fat, followed by characterization and then differentiation into osteocytes both in the presence or absence of exendin‐4. …