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Cell Biology

University of Texas at El Paso

LEDGF/p75

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The Role Of Ledgf/P75 In Transcriptional Regulation, Jeffrey Ryan Kugelman Jan 2010

The Role Of Ledgf/P75 In Transcriptional Regulation, Jeffrey Ryan Kugelman

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The Lens Epithelial Derived Growth Factor p75 (LEDGF/p75) is a chromatin bound protein whose cellular function is not yet clearly known. A role in transcriptional regulation had been previously proposed based on its interaction with the basal transcriptional machinery and on its effects on the expression of genes involved in the cellular response to environmental stresses. To further elucidate the function of LEDGF/p75, we conducted a global and unbiased evaluation of the role of this protein in gene expression. To that aim, we performed a microarray analysis of cellular gene expression in cells that are severely depleted of LEDGF/p75. To …