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Full-Text Articles in Molecular Biology
The Roles Of Malt1 In Nf-Κb Activation And Solid Tumor Progression, Deng Pan
The Roles Of Malt1 In Nf-Κb Activation And Solid Tumor Progression, Deng Pan
Dissertations & Theses (Open Access)
The transcription factor NF-κB plays a central role in many aspects of biological processes and diseases, such as inflammation and cancer. Although it has been suggested thatNF-κB is critical in tumorigenesis and tumor progression, the molecular mechanism by which NF-κB is activated in solid tumor remains largely unknown. In the current work, we focus on growth factor receptor-induced NF-κB activation and tumor progression, including epidermal growth factor receptor (EGFR)-induced NF-κB in lung cancer and heregulin receptor (HER2)-induced NF-κB in breast cancer. We found that Mucosa-associated lymphoma translocation protein 1 (MALT1), also known as paracaspase, is required for EGFR-induced NF-κB activation …
A Novel Function For Aurora B Kinase In The Regulation Of P53 By Phosphorylation, Chris P. Gully
A Novel Function For Aurora B Kinase In The Regulation Of P53 By Phosphorylation, Chris P. Gully
Dissertations & Theses (Open Access)
The mitotic kinase Aurora B plays a pivotal role in mitosis and cytokinesis and governs the spindle assembly checkpoint which ensures correct chromosome segregation and normal progression through mitosis. Aurora B is overexpressed in breast and other cancers and may be an important molecular target for chemotherapy. Tumor suppressor p53 is the guardian of the genome and an important negative regulator of the cell cycle. Previously, it was unknown whether Aurora B and p53 had mutual regulation during the cell cycle. A small molecule specific inhibitor of Aurora B, AZD1152, gave us an indication that Aurora B negatively impacted p53 …