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Full-Text Articles in Molecular Biology
Probing Amyloid-Beta Protein Structure And Dynamics With A Selective Antibody, Shikha Grover
Probing Amyloid-Beta Protein Structure And Dynamics With A Selective Antibody, Shikha Grover
Dissertations
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. The AD brain is characterized by significant neuronal loss and accumulation of insoluble fibrillar amyloid-β protein (Aβ) plaques and tau protein neurofibrillary tangles in the brain. However, over the last decade, many studies have shown that the neurodegenerative effect of Aβ may in fact be caused by various soluble oligomeric forms as opposed to the insoluble fibrils. Furthermore, the data suggest that a pre-fibrillar aggregated form, termed protofibrils, mediates direct neurotoxicity, and triggers a robust neuroinflammatory response.
Antibodies targeting the various conformation of Aβ are important therapeutic agents to prevent the progression …
Interactions Of The Nlrp3 Inflammasome Complex, Nyasha Makoni
Interactions Of The Nlrp3 Inflammasome Complex, Nyasha Makoni
Dissertations
The innate immune system is the first line of defense in response to invasion by pathogens. One of the major pathways in the innate immune system involves a three-protein complex known as the NLRP3 inflammasome. This complex comprises of NLRP3, ASC, and procaspase-1. In response to stimuli, the inflammasome assembles to activate caspase-1 which subsequently facilitates production of interleukin-1β (IL-1β), an inflammatory cytokine. The NLRP3 inflammasome has been implicated in a variety of inflammatory disorders including Alzheimer’s disease (AD). Amyloid beta (Aβ) is the protein that causes AD and Aβ deposits in the brain activate microglia resulting in chronic inflammation. …