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Full-Text Articles in Molecular Biology
Novel Insights Into The Mechanisms Of Regulation Of Tyrosine Kinase Receptors By Ras Interference 1, Adriana Galvis
Novel Insights Into The Mechanisms Of Regulation Of Tyrosine Kinase Receptors By Ras Interference 1, Adriana Galvis
FIU Electronic Theses and Dissertations
Receptor-tyrosine kinases (RTKs) are membrane bound receptors characterized by their intrinsic kinase activity. RTK activities play an essential role in several human diseases, including cancer, diabetes and neurodegenerative diseases. RTK activities have been regulated by the expression or silencing of several genes as well as by the utilization of small molecules.
Ras Interference 1 (Rin1) is a multifunctional protein that becomes associated with activated RTKs upon ligand stimulation. Rin1 plays a key role in receptor internalization and in signal transduction via activation of Rab5 and association with active form of Ras. This study has two main objectives: (1) It determines …