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Full-Text Articles in Molecular Biology
The Rtfa Gene Regulates Plant And Animal Pathogenesis And Secondary Metabolism In Aspergillus Flavus, Jessica Michelle Lohmar
The Rtfa Gene Regulates Plant And Animal Pathogenesis And Secondary Metabolism In Aspergillus Flavus, Jessica Michelle Lohmar
Graduate Research Theses & Dissertations
Aspergillus flavus is an opportunistic fungal plant and human pathogen and producer of mycotoxins including aflatoxin B1 (AFB1). As part of our ongoing studies to elucidate biological functions of the A. flavus rtfA gene, we examined its role in pathogenicity of both plant and animal model systems. rtfA encodes a putative RNA-Pol II transcription elongation factor, previously characterized in Saccharomycese cerevisiae, Aspergillus nidulans, Aspergillus fumigatus, where it was shown to regulate several important cellular processes, including morphogenesis, secondary metabolism. In addition, an initial study in A. flavus indicated that rtfA also influences development and production of AFB1, however its effect …