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Novel Adaptor-Dependent Domains Promote Processive Degradation By Clpxp, Keith L. Rood
Novel Adaptor-Dependent Domains Promote Processive Degradation By Clpxp, Keith L. Rood
Masters Theses 1911 - February 2014
Protein degradation by ATP dependent proteases is a universally conserved process. Recognition of substrates by such proteases commonly occurs via direct interaction or with the aid of a regulatory adaptor protein. An example of this regulation is found in Caulobacter crescentus, where key regulatory proteins are proteolysed in a cell-cycle dependent fashion. Substrates include essential transcription factors, structural proteins, and second messenger metabolism components. In this study, we explore sequence and structural requirements for regulated adaptor mediated degradation of PdeA, an important regulator of cyclic-di-GMP levels.
Robust degradation of PdeA is dependent on the response regulator CpdR in vivo …