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Full-Text Articles in Molecular Biology
Physiological And Evolutionary Implications Of The Pattern Of Expression Of Oxygen-Binding Hemoproteins In Antarctic Notothenioid Fishes, Kimberly Borley
Physiological And Evolutionary Implications Of The Pattern Of Expression Of Oxygen-Binding Hemoproteins In Antarctic Notothenioid Fishes, Kimberly Borley
Electronic Theses and Dissertations
Antarctic icefish do not express hemoglobin (Hb). Icefishes possess cardiovascular modifications including increased densities of blood vessels, larger ventricles and increased blood volume compared to red-blooded relatives. In addition to delivering oxygen to tissues, Hb degrades nitric oxide (NO), a small signaling molecule. To investigate the mechanism driving development of icefish cardiovascular characteristics, I present and test the hypothesis that loss of Hb results in increased steady-state levels of NO, triggering downstream signaling pathways such as angiogenesis. I measured NO breakdown products, as a proxy for NO, and found that icefish have higher steady-state levels of NO metabolites in their …
Alteration Of Nucleotide Excision Repair By Estrogens: Implications For Carcinogenesis, Emily Glynn Notch
Alteration Of Nucleotide Excision Repair By Estrogens: Implications For Carcinogenesis, Emily Glynn Notch
Electronic Theses and Dissertations
Estrogens and estrogen mimics represent a wide range of aquatic contaminants that elicit deleterious effects on exposed organisms. Despite well-characterized reproductive effects of environmental estrogens, less is known about non-reproductive impacts of exogenous estrogen exposure. Additionally, estrogens are known carcinogens, implicated in multiple human cancers. Little or no research has examined the effects of xenoestrogens on DNA repair despite being known carcinogens. The goal of this research was to test the hypothesis that aquatic estrogens enhance the effects of environmental mutagens by altering DNA repair. Of particular interest is nucleotide excision repair (NER), the only repair pathway to remove structurally …