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Biochemistry, Biophysics, and Structural Biology Commons™

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Selected Works

1993

Articles 1 - 3 of 3

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei Sep 1993

Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei

Amy Sprenkle

The protease, a-thrombin (aTh), affects myocardial cell contractility, a feature common among agents that induce hypertrophy. However, it is not known whether cardiac myocytes possess aTh receptors (aTh-R), or if long term treatment with aTh can enhance growth and gene expression. In the present study primary neonatal rat ventricular myocytes expressed a 3.6-kilobase mRNA species that hybridized with a rat aTh-R-specific probe. After 48 h, aTh induced hypertrophy, sarcomeric organization, and enhanced atrial natriuretic factor (ANF) expression, all of which were blocked by the aTh-selective protease inhibitor, D-Phe-Pro-Argchloromethyl ketone. The aTh-R agonist peptide, SFLLRNPND, was a potent activator of ANF …

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Functional Explanation And Metaphysical Individualism, Justin Schwartz Jan 1993

Functional Explanation And Metaphysical Individualism, Justin Schwartz

Justin Schwartz

A number of (present or former) analytical Marxists, such as Jon Elster, have argued that functional explanation has almost no place in the social sciences. (Although the discussion is framed in terms of a debate among analytical Marxists, the point is quite general, and Marxism is used for illustrative purposes.) Functional explanation accounts for what is to be explained by reference to its function; thus, sighted organism have eyes because eyes enable them to see. Elster and other critics of functional explanation argue that this pattern of explanation is inconsistent with "methodological individualism," the idea, as they understand it, that …

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Acute Toxicity Of The Bird Repellent, Methyl Anthranilate, To Fry Of Salmo Salar, Oncorhynus Mykiss, Ictalurus Punctatus And Lepomis Macrochirus, Larry Clark, John Cummings, Steven Bird, Eugeny Aronov Jan 1993

Acute Toxicity Of The Bird Repellent, Methyl Anthranilate, To Fry Of Salmo Salar, Oncorhynus Mykiss, Ictalurus Punctatus And Lepomis Macrochirus, Larry Clark, John Cummings, Steven Bird, Eugeny Aronov

Larry Clark

Several laboratory and field studies have shown methyl anthranilate to be an effective, non-toxic and non-lethal bird repellent, with application potential for protecting crops, seeds, turf and fish stocks from bird damage. Furthermore, methyl anthranilate can be added to liquids for the purposes of protecting nigratory birds, e.g. addition to waste water associated with mining and to standing water pools at airports. Mammalian toxicity data are favorable. Methyl anthranilate is used as a fragrance and food flavoring and is GRAS listed by the US Food and Drug Administration. Despite the favorable outlook for methyl anthranilate's use as a safe repellent, …

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