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Biochemistry, Biophysics, and Structural Biology Commons™

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Selected Works

1993

Articles 1 - 5 of 5

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Thermodynamics Of Single-Stranded Rna And Dna Interactions With Oligolysines Containing Tryptophan. Effects Of Base Composition., David Mascotti, Timothy Lohman Oct 1993

Thermodynamics Of Single-Stranded Rna And Dna Interactions With Oligolysines Containing Tryptophan. Effects Of Base Composition., David Mascotti, Timothy Lohman

David P. Mascotti

No abstract provided.

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Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei Sep 1993

Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei

Amy Sprenkle

The protease, a-thrombin (aTh), affects myocardial cell contractility, a feature common among agents that induce hypertrophy. However, it is not known whether cardiac myocytes possess aTh receptors (aTh-R), or if long term treatment with aTh can enhance growth and gene expression. In the present study primary neonatal rat ventricular myocytes expressed a 3.6-kilobase mRNA species that hybridized with a rat aTh-R-specific probe. After 48 h, aTh induced hypertrophy, sarcomeric organization, and enhanced atrial natriuretic factor (ANF) expression, all of which were blocked by the aTh-selective protease inhibitor, D-Phe-Pro-Argchloromethyl ketone. The aTh-R agonist peptide, SFLLRNPND, was a potent activator of ANF …

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Genetic Analyses Of Photopigment Biosynthesis In Eubacteria: A Guiding Light For Algae And Plants, David Bollivar, Carl E. Bauer, Jon Y. Suzuki Jun 1993

Genetic Analyses Of Photopigment Biosynthesis In Eubacteria: A Guiding Light For Algae And Plants, David Bollivar, Carl E. Bauer, Jon Y. Suzuki

David Bollivar

A wide variety of macrocyclic tetrapyrrole compounds are synthesized by cells for use in diverse cellular processes. As shown in Fig. 1, this pathway includes the synthesis of closed tetrapyrrole compounds that contain metals, such as cobalt-containing cobalamin (vitamin B12), nickel-containing methanogenesis coenzyme F430, copper-containing pigment turacin, iron-containing heme and siroheme, and magnesium-containing chlorophylls and bacteriochlorophylls. Also synthesized by this pathway are a variety of open macrocyclic compounds such as the family of bilins that are used as a source of light-harvesting pigments in cyanobacteria, red algae, and cryptophytes as well as the chromophore that is covalently attached to phytochrome …

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Functional Explanation And Metaphysical Individualism, Justin Schwartz Jan 1993

Functional Explanation And Metaphysical Individualism, Justin Schwartz

Justin Schwartz

A number of (present or former) analytical Marxists, such as Jon Elster, have argued that functional explanation has almost no place in the social sciences. (Although the discussion is framed in terms of a debate among analytical Marxists, the point is quite general, and Marxism is used for illustrative purposes.) Functional explanation accounts for what is to be explained by reference to its function; thus, sighted organism have eyes because eyes enable them to see. Elster and other critics of functional explanation argue that this pattern of explanation is inconsistent with "methodological individualism," the idea, as they understand it, that …

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Acute Toxicity Of The Bird Repellent, Methyl Anthranilate, To Fry Of Salmo Salar, Oncorhynus Mykiss, Ictalurus Punctatus And Lepomis Macrochirus, Larry Clark, John Cummings, Steven Bird, Eugeny Aronov Jan 1993

Acute Toxicity Of The Bird Repellent, Methyl Anthranilate, To Fry Of Salmo Salar, Oncorhynus Mykiss, Ictalurus Punctatus And Lepomis Macrochirus, Larry Clark, John Cummings, Steven Bird, Eugeny Aronov

Larry Clark

Several laboratory and field studies have shown methyl anthranilate to be an effective, non-toxic and non-lethal bird repellent, with application potential for protecting crops, seeds, turf and fish stocks from bird damage. Furthermore, methyl anthranilate can be added to liquids for the purposes of protecting nigratory birds, e.g. addition to waste water associated with mining and to standing water pools at airports. Mammalian toxicity data are favorable. Methyl anthranilate is used as a fragrance and food flavoring and is GRAS listed by the US Food and Drug Administration. Despite the favorable outlook for methyl anthranilate's use as a safe repellent, …

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