Open Access. Powered by Scholars. Published by Universities.®
Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Prolactin (3)
- Breast Cancer (2)
- Cryptococcus neoformans (2)
- DNA glycosylase (2)
- DNA repair (2)
-
- Entamoeba histolytica (2)
- MicroRNA (2)
- Trypanosoma brucei (2)
- : Multidrug resistance-associated protein 2 (1)
- AKT (1)
- ARF inhibitor (1)
- Acetate (1)
- Acetate metabolism (1)
- Ago2 (1)
- Albumin binding (1)
- Allosteric Enzyme (1)
- Allosteric Regulation (1)
- Allosteric enzyme (1)
- Amoeba (1)
- Amoebic dysentery (1)
- Antagonist (1)
- Antarctica (1)
- Apoptosis (1)
- Aquilegia (1)
- Arsenic (1)
- Bioinformatics (1)
- Biophysics (1)
- Breast Cancer Research (1)
- Breast cancer (1)
- C2C12 cells (1)
- Publication Year
- Publication
Articles 31 - 33 of 33
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Dendrimer Supramolecular Assembly For Gene Delivery, Karthikeyan Pasupathy
Dendrimer Supramolecular Assembly For Gene Delivery, Karthikeyan Pasupathy
All Theses
Dendrimers have found many applications in the fields of polymer science, biophysics, nanomedicine and the petroleum industry. Poly(amidoamine) (PAMAM) was studied as a model dendrimer and squalane as a model hydrocarbon. The interaction between PAMAM and squalane is pH dependent. Specifically, at low or neutral pH the squalane is found on the periphery of the PAMAM while at high pH the hydrocarbon is entrapped inside the PAMAM molecules.
Single-molecule fluorescence revealed that the interaction between PAMAM and squalane is reversible. At a pH value of 8, the time constants for the approaching, binding and dissociation of single PAMAM to squalane …
Development Of Novel Prolactin And Growth Hormone Receptor Agonists And Antagonists, John Langenheim
Development Of Novel Prolactin And Growth Hormone Receptor Agonists And Antagonists, John Langenheim
All Dissertations
Potential indications for human prolactin (hPRL) and human growth hormone (hGH) are the support and sustainment of lactation and the enhancement or reconstitution of the immune system when under dysregulation. A prolactin receptor (PRLR) antagonist, hPRL-G129R (G129R), and a PRLR and growth hormone receptor (GHR) antagonist, hGH-G120R (G120R), have been developed which may be useful for the treatment of breast cancer since PRLR is elevated in a majority of human breast tumors and makes cancer cells highly sensitive to the mitogenic and anti-apoptotic activity of hPRL and hGH.
As a single agent, G129R is more cytostatic than cytotoxic to human …
The Role Of Prolactin And Its Antagonist In Her2/Neu Tumorigenesis, Michele Scotti
The Role Of Prolactin And Its Antagonist In Her2/Neu Tumorigenesis, Michele Scotti
All Dissertations
Purpose: To study the role of prolactin (PRL) and its antagonist, G129R, in HER2/Neu tumorigenesis. Specifically, to investigate the interaction between the oncogene HER2 and the PRL receptor (PRLR) signaling pathways for designing effective combinational therapeutics for breast cancer.
Experimental Design: The combination effects of G129R and an anti-HER2 antibody, Herceptin, were tested against HER2-overexpressing human breast cancer cell lines, T-47D and BT-474, using cell based assays and xenografts established in athymic mice. Furthermore, four different bitransgenic mouse lines co-expressing the murine version of HER2 and PRL or G129R were generated. The mammary tumor incidence, characterization of mammary gland development, …