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Biochemistry, Biophysics, and Structural Biology Commons

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Cell and Developmental Biology

City University of New York (CUNY)

Alternative Polyadenylation

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

The Role And Regulation Of Alternative Polyadenylation In The Dna Damage Response, Michael R. Murphy May 2019

The Role And Regulation Of Alternative Polyadenylation In The Dna Damage Response, Michael R. Murphy

Dissertations, Theses, and Capstone Projects

Cellular homeostasis is achieved by the dynamic flux in gene expression. Post-transcriptional regulation of coding and non-coding RNA offers a fast method of adapting to a changing cellular environment, including deadenylation, microRNA (miRNA) pathway, and alternative polyadenylation (APA). In this dissertation, I explored some of the mechanisms involved in the post-transcriptional regulation of gene expression. The main hypothesis in these studies is that a single APA event after DNA damage is governed by specific conditions and factors outside of current known regulators of APA, and that the resultant transcript has a role in the DNA damage response (DDR). My aims …